Human Dipeptidyl-peptidase I

Dipeptidyl Peptidase-4 Inhibitor

In the United States, nearly 13% of adults aged 20 years and older have type 2 diabetes mellitus (T2DM), and its prevalence is still increasing (1,2). Microvascular and macrovascular abnormalities are common in patients with T2DM and are related to the severity and duration of hyperglycemia (3–5). Thus, treatment of hyperglycemia is an important way to prevent or delay diabetic vascular complic...

Targeting Dipeptidyl Peptidase IV (CD26)

Murine Neutrophil Chemorepellent Dipeptidyl Peptidase IV Is a Human and

Dipeptidyl peptidase IV in human lymphocytes: molecular properties.

Dipcptidyl peptidase IV (DPP IV; EC 3.4.14.5). an cctocnzyme o n the cell membrane of T-lymphocytes, has bccn shown t o play an important role in the regulation of lymphocyte proliferation and activation. Evidence for this has been provided by the use of specific inhibitors, which revealed (a) a supprcssion of the proliferation of peripheral blood lymphocytes by mitogenic lectins 111, and (b) a...

Dipeptidyl peptidase 8/9-like activity in human leukocytes.

The proline-specific dipeptidyl peptidases (DPPs) are emerging as a protease family with important roles in the regulation of signaling by peptide hormones. Inhibitors of DPPs have an intriguing, therapeutic potential, with clinical efficacy seen in patients with diabetes. Until now, only recombinant forms of DPP8 and DPP9 have been characterized. Their enzymatic activities have not been demons...